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Frontiers of Knowledge Awards 2015

Gero Miesenböck has won a BBVA Foundation Frontiers of Knowledge Award for the development of optogenetics. He shares the € 400,000 prize with Edward Boyden of MIT and Karl Deisseroth of Stanford University.

Optogenetics, according to the citation, “has revolutionized the study of brain function and is now used by neuroscientists around the world.” Understanding the brain’s function “would require the development of a technology that allowed the selective control of individual neurons without affecting the activity of others. Optogenetics is this technology: it allows the activation and inactivation of neurons in living animals, and therefore can be used to make causal links between the function of specific neural circuits and distinct behaviors.”

The Frontiers of Knowledge Awards aim “to recognize and encourage world-class research and artistic creation, prizing contributions of lasting impact for their originality, theoretical significance and ability to push back the frontiers of the known world.”

BBVA Foundation Frontiers of Knowledge Awards

Selective photostimulation of genetically chARGed neurons

Transmission of olfactory information between three populations of neurons in the antennal lobe of the fly

Photochemical gating of heterologous ion channels: remote control over genetically designated populations of neurons

Optical imaging and control of genetically designated neurons in functioning circuits

Remote control of behavior through genetically targeted photostimulation of neurons

Excitatory local circuits and their implications for olfactory processing in the fly antennal lobe

Sex-specific control and tuning of the pattern generator for courtship song in Drosophila

Rational optimization and imaging in vivo of a genetically encoded optical voltage reporter

Lighting up the brain