Flies neglect food and endure shocks to seek a dopamine reward
Oct 27, 2023
Oct 27, 2023
Aug 31, 2023
This September, Dr Rui Ponte Costa relocates his Neural and Machine Learning group to DPAG and will be based at the CNCB. He was previously a Senior Lecturer in Computational Neuroscience and Machine Learning at the University of Bristol. His research group focuses on producing AI-driven brain-wide computational models of learning. Dr Rui Ponte Costa began...
Read moreMay 10, 2023
Congratulations are in order to Scott Waddell on his election to The Royal Society. Professor Scott Waddell FMedSci FRS is DPAG's Professor of Neurobiology and Wellcome Trust Principal Research Fellow in Basic Biomedical Science at the Centre for...
Read moreJan 24, 2023
Professor Gero Miesenböck, DPAG's Waynflete Professor of Physiology and Director of the Centre for Neural Circuits and Behaviour, is one of two scientists to be awarded the 2023 Japan Prize "for their development of methods that use genetically addressable light-sensitive membrane proteins to unravel neural circuit function". Head of Department Professor...
Read moreMay 12, 2021
Professor Scott Waddell FMedSci has been elected a Fellow of the Academy of Medical Sciences. All new Fellows are selected by the prestigious National Academy for their exceptional contributions to the advancement of medical science through innovative research discoveries and translating scientific...
Read moreMay 21, 2020
For his foundational work on "the development of optogenetics, a technology that has revolutionized neuroscience", Gero Miesenböck is to receive the 2020 Shaw Prize in Life Sciences and Medicine. The Shaw Prize is regarded as the preeminent international recognition for scientific achievement among awards originating in Asia. Miesenböck was named the winner of the prize, along with Peter Hegemann of Humboldt University and Georg Nagel of...
Read moreJul 17, 2019
The 2019 Warren Alpert Foundation Prize has been awarded to four scientists for pioneering work in the field of optogenetics, 'a revolutionary technique that uses light and genetic modification to control the activity of cells in the brain.' Gero Miesenböck is recognised 'for the first demonstrations of optogenetic control of neural activity and animal behaviour and for discoveries proving the...
Read moreApr 11, 2019
Sleep deprivation elevates mitochondrial reactive oxygen species in sleep-promoting neurons, which register this rise with the help of a redox-sensitive ion channel. The resulting changes in electrical excitability close a molecular feedback loop that leads to the induction of sleep. It is no accident that oxygen tanks carry explosion hazard labels: uncontrolled combustion is dangerous. Humans and animals face similar risks when...
Read moreApr 8, 2019
Gero Miesenböck is among the recipients of the 2018 Rumford Prize. He is honoured for the invention of optogenetics, along with colleagues responsible for subsequent refinements. The Rumford Prize, awarded by the American Academy of Arts and Sciences, is one of the oldest scientific prizes in the United States. It recognises contributions to the fields of 'heat and...
Read moreMar 28, 2019
Gero Miesenböck was awarded and ERC Advanced Grant to investigate the homeostatic regulation and biological function of sleep. The project will seek to identify the molecular changes that drive sleep-inducing neurons in the fly brain into the electrically active state. Gero said: 'I’m thrilled this worked out—especially since this may have been the last chance for UK residents to apply. The ERC is one of the very few funding agencies...
Read moreJan 23, 2019
Oct 17, 2018
Gero Miesenböck is giving the 2018 Francis Crick Lecture at the MRC Laboratory of Molecular Biology in Cambridge on 24 October. The Crick Lecture, named in honour of the late LMB Nobel Laureate, is one of a series of named lectures organised...
Read moreOct 8, 2018
Fear memories allow animals to predict and avoid possibly dangerous situations. However, if an expected threat does not happen, it is also important to learn to be less fearful. This re-learning process is called memory extinction. Although extinction has been postulated for many years to involve parallel memories, it is unclear how and where extinction memories are formed and how they compete with the original memory to neutralise learned fear....
Read moreApr 26, 2018
Subthreshold changes in membrane voltage represent accumulating evidence before a choice. The transcription factor FoxP sets neuronal integration and behavioural decision times. Decisions take time because the information needed to make them is rarely available all at once but must be gathered sequentially. We know from our own experience that decisions tend to be quick when the choice is unambiguous but protracted when evidence is...
Read moreJul 26, 2017
The shape and function of every cell in our body is determined by the amount and types of protein molecules that they produce. The building plan for each cell is stored in the DNA of the genome. This information is carefully copied and passed on to daughter cells during the reproduction, development and growth of all living organisms. Any changes (mutations) that occur in the DNA of each cell could potentially have devastating effects on the...
Read moreApr 20, 2017
The bus doesn’t always arrive on time and your favourite dish is not always on the menu at the local restaurant. To account for an ever-changing world, animals must possess neural mechanisms to constantly update their learned predictions so that their choices correctly incorporate the new, sometimes contradicting information. A recent study from the Waddell lab in Nature reveals how the strength of memory-directed behavior is...
Read moreJan 4, 2017
Gero Miesenböck will give the 2017 Weizmann Memorial Lectures at the Weizmann Institute of Science. The annual lecture series commemorates the founder of the Institute, Dr. Chaim Weizmann. The lectures are intended to review the state of the art and the newest developments in a chosen field. The series usually consists of two...
Read moreAug 15, 2016
Gero Miesenböck has won the Massry Prize 2016 for his work on optogenetics. He shares the award with Karl Deisseroth of Stanford University and Peter Hegemann of the Humboldt-Universität zu Berlin. Optogenetics uses light-operated switches to control the electrical impulses of nerve cells. The ability to remote-control neuronal function has had a profound impact on...
Read moreAug 3, 2016
Sleep-promoting neurons switch between electrical activity and silence as a function of sleep need. The switch is operated by dopamine and involves the antagonistic regulation of two potassium channels. Sleep is one of the great biological mysteries. Each night we disconnect ourselves from the world for 7 or 8 hours—a state that leaves us vulnerable and unproductive. Yet despite these risks and costs, we do not know what sleep is...
Read moreMay 19, 2016
Hunger promotes the behavioural expression of food-seeking memories. A recent study from the Waddell lab in Neuron discovered the neural circuit mechanism that provides this control. Hunger-state modulation increases the activity of a pair of inhibitory interneurons of the mushroom body so that odours more strongly drive mushroom body output pathways that favour approach behaviour. Surprisingly aversive learning promotes odour avoidance...
Read moreMar 3, 2016
Memories are stored in the fan-out fan-in neural architectures of the mammalian cerebellum and hippocampus and the insect mushroom bodies. However, whereas key plasticity occurs at glutamatergic synapses in mammals, the neurochemistry of the memory-storing mushroom body Kenyon cell output synapses has been debated for decades. A recent study from the Waddell lab in Neuron shows acetylcholine is a Kenyon cell neurotransmitter in...
Read moreJan 26, 2016
Gero Miesenböck has won a BBVA Foundation Frontiers of Knowledge Award for the development of optogenetics. He shares the € 400,000 prize with Edward Boyden of MIT and Karl Deisseroth of Stanford University. Optogenetics, according to the citation, “has revolutionized the study of brain function and is now used by neuroscientists around the world.” Understanding the brain’s function “would require the development of a technology...
Read moreSep 15, 2015
Gero Miesenböck will receive the Heinrich Wieland Prize 2015 for his conception and first experimental demonstration of optogenetics.
Named after the 1927 Chemistry Nobel Laureate Heinrich Wieland, the annual award recognises outstanding research on biologically active molecules and systems. It is among the most prestigious international science prizes awarded in Germany.
To find out more
May 1, 2015
The Royal Society is the national Academy of science in the UK. Its Fellowship is made up of the most eminent scientists, engineers, and technologists from or living and working in the UK and the Commonwealth. The Society’s fundamental purpose, reflected in its founding Charters of the 1660s, is to recognise, promote, and support excellence in science and to encourage the development and use...
Read moreApr 9, 2015
Finding locations in the brain where memories are formed, and understanding how memories are retrieved to instruct behaviour, are major goals of neuroscience. A recent study from the Waddell lab in Neuron localised memories to specific pathways in the output network of the fruit fly mushroom bodies. Surprisingly, reward and punishment learning altered odour-driven-activity of this connection in opposite directions. Moreover, it was...
Read moreDec 22, 2014
Scott Waddell has received the Liliane Bettencourt Prize for Life Sciences 2014. Each year, the Bettencourt Schueller Foundation awards the Prize to a young researcher (under 45), recognized in the scientific community for the quality of his or her international publications. In addition to the recipient’s scientific recognition, the award-winning researcher must conduct a research project that is particularly promising and be able to...
Read moreDec 19, 2014
Tim Vogels is among 20 young European neuroscience researchers chosen to be the first FENS-Kavli Scholars. The Federation of European Neuroscience Societies (FENS) and The Kavli Foundation have announced the first FENS-Kavli Scholars, chosen for the excellence of their research, as well as promise to be among the field’s newest generation of extraordinary pioneers. Launched this year, the FENS-Kavli Network of Excellence aims to...
Read moreNov 17, 2014
Drinking water is innately rewarding to thirsty animals. A recent study from the Waddell lab in Nature Neuroscience demonstrated that neural circuit mechanisms of water wanting, learning and liking can be distinguished by their requirements for dopaminergic neurons in the brain of thirsty flies. The full paper can be viewed Lin et al. (2014). Suewei Lin...
Read moreOct 3, 2014
Professor Martin Booth has been awarded the ICO Prize 2014 by the International Commission for Optics for “his innovative and pioneering research on dynamic optical methods and new approaches to adaptive optics”. Booth’s research primarily concerns the development of dynamic optical methods for a range of interdisciplinary applications. A major application is the use of adaptive optics for aberration correction in high-resolution...
Read moreMay 22, 2014
Fruit flies take time to deliberate when faced with difficult decisions. The process is linked to FoxP, a gene associated with cognitive development and language in humans. Have you ever agonized over a difficult decision? Reflecting before committing to a choice is considered a hallmark of intelligence. In a study published in the journal Science, CNCB researchers report that fruit flies also ‘think’ before they...
Read moreMay 7, 2014
Prof Scott Waddell, Wellcome Trust Senior Research Fellow and Deputy Director of the CNCB, has been elected as a Member of EMBO, in recognition of his molecular biology-directed studies of brain function in Drosophila. EMBO has announced today on the occasion of its 50thanniversary that 106 researchers in the life sciences were newly elected to its membership. Of these, one hundred scientists reside in Europe and neighbouring...
Read moreFeb 23, 2014
Sparse odour coding by the Kenyon cells of the mushroom body generates a large number of precisely addressable locations for the storage of odour-specific memories. Anyone who associates the smell of freshly baked apple pie with happy childhood memories or the smell of disinfectant with a flu jab knows the power of associative memory, especially of associations with odours. But how do we attach distinct memories to the millions of...
Read moreFeb 19, 2014
A small group of neurons put flies to sleep when they need to rest. The body uses two mechanisms to regulate sleep. One is the body clock, which attunes humans and animals to the 24 hour cycle of day and night. The other mechanism is the sleep ‘homeostat’: a device in the brain that keeps track of your waking activity and puts you to sleep when you are tired and need to reset. This mechanism is purely internal. When it...
Read moreOct 8, 2013
Dr Brian Patton is recognised by The Royal Society for his work on imaging deep tissue neural processes using nanodiamonds (ND).
Dr Brian Patton of the Centre for Neural Circuits and Behaviour at Oxford University is among just 41 scientists appointed by The Royal Society as
Oct 2, 2013
Gero Miesenböck is one of this year's recipients of the Jacob Heskel Gabbay Award in Biotechnology and Medicine. The award, presented by the Rosenstiel Center of Brandeis University in Massachusetts, is in recognition of the recipients' ‘contributions to the discovery and applications of optogenetics’. In addition to Gero Miesenböck, Karl Deisseroth of Stanford University and Edward S. Boyden of the Massachusetts Institute of...
Read moreSep 9, 2013
A CNCB double bill—papers from the Miesenböck and Waddell groups—appears in the September 4 issue of Neuron. Click here to read Moshe Parnas, Andrew Lin, Wolf Huetteroth and Gero Miesenböck on 'Odor discrimination in Drosophila: from neural population codes to behavior.' Read more
Apr 27, 2013
CNCB team shows that the neural reward system of flies is more similar to that of mammals than previously thought. A team led by Scott Waddell of the Centre for Neural Circuits and Behaviour shows that the fruit fly brain contains an evaluation system that is more similar to mammals than previously recognised. The research, published in Nature this month, demonstrates that the neurotransmitter dopamine, which is synonymous...
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Professor Gero Miesenböck, Director of the Centre for Neural Circuits and Behaviour at the University of Oxford, has been awarded The Brain Prize 2013 "for the invention and refinement of optogenetics." Miesenböck was the first scientist who modified nerve cells genetically to produce light-responsive pigments. By shining light on the pigment-producing cells he caused them to become electrically active. The function of the nerve cells could...
Read moreNov 1, 2012
Dr Korneel Hens joins CNCB as Group Leader, to explore how regulatory networks in neurons act to integrate and respond to incoming information, supporting the Centre's research into how intelligence emerges from the physical interaction of nerve cells. Professor Gero...
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